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We consider a revenue-maximizing seller with m heterogeneous items and a single buyer whose valuation for the items may exhibit both substitutes and complements. We show that the better of selling the items separately and bundling them together— guarantees a [Formula: see text]-fraction of the optimal revenue, where d is a measure of the degree of complementarity; it extends prior work showing that the same simple mechanism achieves a constant-factor approximation when buyer valuations are subadditive (the most general class of complement-free valuations). Our proof is enabled by a recent duality framework, which we use to obtain a bound on the optimal revenue in the generalized setting. Our technical contributions are domain specific to handle the intricacies of settings with complements. One key modeling contribution is a tractable notion of “degree of complementarity” that admits meaningful results and insights—we demonstrate that previous definitions fall short in this regard.